Lansdown picked up their second win of the season as they saw off Knowle by 130 runs.
Skipper Thomas Hankins won the toss, chose to bat and tallied 84 runs of his own, taking part in a 128-run partnership with J Addey (51).
Jackson Hamilton also struck 40 from 33 balls to add late impetus and take Lansdown to 256-8 from their 50 overs.
The Knowle reply was held up by rain at 13.4 overs, which saw their target reduced to 233.
But they never looked like coming close as Anant Tambvekar took four early wickets to reduce them to 72-5.
Matt Thomas also claimed 3-25 as Knowle were skittled for just 126 with only three of their allotted overs remaining..